MeVit B12 1000mcg 30 tableta

1. sublingvalna primena - brza apsorpcija, nezavisna od digestivnih faktora (ref.1,2,3,4,5)
• podjezično je prisutna bogata mreža krvnih sudova te je apsorpcija direktna
• nezavisna od želudacne pH i prisustva "intrising" faktora
• prikladna za osobe sa otežanim gutanjem

2. adekvatna zamena za injekcioni oblik vitamina B12 (ref.3)
• neinvazivna i komforna primena
• studije pokazuju bolju kompliansu sublingvalne formulacije od strane pacijenata

3. metilkobalamin kao aktivni oblik vitamina B12 (ref.6)
• direktno iskoristiv
• ne zahteva transformaciju u organizmu

Reference:1. Delpre G, Stark P, Niv Y. Sublingual therapy for cobalamin de_ciency as an alternative to oral and parenteral cobalamin supplementation. Lancet1999;354(9180):740-741. 2.
Sharabi A, Cohen E, Sulkes J, Garty M. Replacement therapy for vitamin B12 de_ciency: comparison between the sublingual and oral route. Br J ClinPharmacol2003;56(6):635–638. 3.
Kwong JC, Carr D, Dhalla IA, Tom-Kun D, Upshur RE. Oral vitamin B12 therapy in the primary care setting: a qualitative and quantitative study of patient perspectives. BMC Fam
Pract2005;6(1):8. 4. Yazaki Y, Chow G, Mattie M. A single-center, double-blinded, randomized controlled study to evaluate the relative e_cacy of sublingual and oral vitamin B-complex
administration in reducing total serum homocysteine levels. J Altern Complement Med. 2006;12(9):881-5. 5. Stabler SP. Vitamin B12 de_ciency. N Engl J Med2013;368(21):2041-2. 6.
Thakkar K, Billa G. Treatment of vitamin B12 de_ciency–Methylcobalamine? Cyancobalamine? Hydroxocobalamin?—clearing the confusion. European Journal of Clinical
Nutrition2015;69(1):1–2.